tramadol induced seizure: a 3-year study

نویسندگان

reza boostani

siavash derakhshan

چکیده

background: tramadol is a synthetic analgesic. seizures have been reported in patients receiving this drug. in this study we evaluated the correlation between tramadol consumption and seizure occurrence. methods: twenty-eight subjects with a history of tramadol consumption and seizure were studied. electroencephalograms (eeg) were performed in the first 24 hours and again one week later. subjects were followed up for a mean of 18 months after the initial attack. results: in the 28 subjects, 26 (92.8%) were males and 2 (7.2%) were females. the mean age of the subjects was 28.4 years. thirteen patients had abused more than 400 mg/day of tramadol. sixteen subjects concomitantly used other drugs. the seizures occurred within the first 24 hours of tramadol intake in 25 of the subjects. the first eeg was abnormal in 12 cases, but the second eeg was abnormal in only one case. neuroimaging of only one subject displayed patchy white matter lesions. conclusion: in conclusion, the neurotoxicity of tramadol commonly manifests as generalized tonic clonic seizures most frequently within 24 hours after tramadol intake and was more common in subjects concomitantly consuming alcohol, illicit drugs, anti-psychotics, or anti-depressants.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Tramadol induced seizure: A 3-year study

Background: Tramadol is a synthetic analgesic. Seizures have been reported in patients receiving this drug. In this study we evaluated the correlation between tramadol consumption and seizure occurrence. Methods: Twenty-eight subjects with a history of tramadol consumption and seizure were studied. Electroencephalograms (EEG) were performed in the first 24 hours and again one week later. Subje...

متن کامل

Intravenous Tramadol-Induced Seizure: Two Case Reports

There are a few reports of seizure induced by tramadol at therapeutic dose. Two case reports of repeated seizures with following agitation due to treatment with tramadol are presented here. Both of them have similar presentation and tramadol was injected intravenously at therapeutic doses. Tramadol prescription especially intravenously can evoke seizure with agitation or even status epilepticus...

متن کامل

Tramadol Induced Seizure: Report of 106 Patients

Background: Seizure is one of the possible adverse effects of tramadol hydrochloride, a synthetic, centrallyacting analgesic, prescribed for the treatment of moderate to severe pain. In this study, we describe 106 patients with tramadol induced seizures. Methods: The patients, who were referred to Nemazee Hospital, Shiraz, Iran, from March 2006 to March 2008, were examined in this cross-section...

متن کامل

Prevalence of Tramadol Consumption in First Seizure Patients; a One-Year Cross-sectional Study

INTRODUCTION Previous studies have shown that there is a probability of seizure even with therapeutic doses of tramadol. Yet, no accurate data exist regarding this problem in Iran. Therefore, the present study aimed to evaluate the prevalence of tramadol consumption in patients with first seizure referred to the emergency department (ED). METHODS In the present retrospective one-year cross-se...

متن کامل

Seizure-Induced Thoracolumbar burst Fracture Secondary to Tramadol Abuse

Tramadol is a novel centrally acting opioid analgesic used for the treatment of mild to severe pain. This drug is the most prescribed opioid worldwide. It has been approved as an analgesic in Iran since 2002. Unfortunately Tramadol dependency has become very common in Iran in various age groups and genders but in particular is abused among the young generation. Overdose of Tramadol is a well-kn...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
caspian journal of internal medicine

جلد ۳، شماره ۳، صفحات ۴۸۴-۴۸۷

کلمات کلیدی

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023